Which alternative to BIOFEN EXTRA 400 mg/325 mg is the cheapest?

Combifexin 200mg/500mg, 10 comprimate, Sandoz is the cheapest same-INN alternative listed — 14.99 RON, 23.40 RON below the current price of BIOFEN EXTRA 400 mg/325 mg. It contains the same active substance (COMBINATII (IBUPROFENUM+PARACETAMOLUM)); the brand, the pack and sometimes the excipients differ.

Are these alternatives therapeutically equivalent?

Generics with the same INN have the same active substance and are assessed by the European Medicines Agency (EMA) for bioequivalence. Differences appear in the excipients (relevant for patients with specific food allergies — e.g. lactose), the brand and the manufacturer. Even so, the decision to switch rests with the doctor or pharmacist; do not change a chronic treatment without consultation.

Can I replace BIOFEN EXTRA 400 mg/325 mg with a generic without consulting the doctor?

For OTC (over-the-counter) medicines you can ask the pharmacist for an alternative with the same INN — this is accepted practice. For prescription medicines, substitution happens either through an INN prescription (the doctor prescribes the active substance, not the brand) or with the doctor's agreement. HartaFarmacii shows alternatives for information — this is not a medical recommendation.

Cheaper alternatives to BIOFEN EXTRA 400 mg/325 mg

In short: for BIOFEN EXTRA 400 mg/325 mg (active substance: COMBINATII (IBUPROFENUM+PARACETAMOLUM)) there are 4 equivalent medicines with the same INN on HartaFarmacii, 3 of which are cheaper than the current product. The cheapest alternative is Combifexin 200mg/500mg, 10 comprimate, Sandoz, at 14.99 RON — 23.40 RON below the reference price of 38.39 RON. Equivalents with the same INN contain the same active substance, but switching a treatment requires the doctor's agreement — ask the pharmacist before any substitution.

For the active substance COMBINATII (IBUPROFENUM+PARACETAMOLUM) 400mg/325mg, we found 4 equivalent medicines with the same INN, with prices updated daily. Reference price for BIOFEN EXTRA 400 mg/325 mg: 38.39 RON.

Cheapest alternative: Combifexin 200mg/500mg, 10 comprimate, Sandoz

14.99 RON

You save 23.40 RON compared with BIOFEN EXTRA 400 mg/325 mg See the full page: Combifexin 200mg/500mg, 10 comprimate, Sandoz →

Generics with the same INN

The same active substance (COMBINATII (IBUPROFENUM+PARACETAMOLUM)), a different brand or manufacturer. Sorted by price, lowest first.

Generic vs original — in short

Generics contain the same active substance (INN) as the original product, at the same dose and in the same pharmaceutical form. To be authorised they must demonstrate bioequivalence — that is, a similar pharmacokinetic profile (the blood concentration over time is within ±20%). Typical differences are in the excipients (relevant for patients allergic to lactose, gluten or colourings), the brand and the manufacturer. For chronic treatments, switching from one generic to another is done with the doctor's agreement — even if the active substance is identical, individual tolerance can differ.

Frequently asked questions

Which alternative to BIOFEN EXTRA 400 mg/325 mg is the cheapest?

Combifexin 200mg/500mg, 10 comprimate, Sandoz is the cheapest same-INN alternative listed — 14.99 RON, 23.40 RON below the current price of BIOFEN EXTRA 400 mg/325 mg. It contains the same active substance (COMBINATII (IBUPROFENUM+PARACETAMOLUM)); the brand, the pack and sometimes the excipients differ.
Are these alternatives therapeutically equivalent?

Generics with the same INN have the same active substance and are assessed by the European Medicines Agency (EMA) for bioequivalence. Differences appear in the excipients (relevant for patients with specific food allergies — e.g. lactose), the brand and the manufacturer. Even so, the decision to switch rests with the doctor or pharmacist; do not change a chronic treatment without consultation.
Can I replace BIOFEN EXTRA 400 mg/325 mg with a generic without consulting the doctor?

For OTC (over-the-counter) medicines you can ask the pharmacist for an alternative with the same INN — this is accepted practice. For prescription medicines, substitution happens either through an INN prescription (the doctor prescribes the active substance, not the brand) or with the doctor's agreement. HartaFarmacii shows alternatives for information — this is not a medical recommendation.

The lists of alternatives are built automatically from the INN field and the therapeutic category in our database — they are NOT a medical recommendation. For therapeutic substitution, consult the doctor or pharmacist. See the methodology and the editorial team.